Appeal No. 2001-0762 Page 2
Application No. 08/343,585
The references relied upon by the examiner are:
Flouret et al. (Flouret), “The synthesis of D-Oxytocin, the enantiomer of the
posterior pituitary hormone, oxytocin,” J. Am. Chem. Soc., Vol. 87, No. 16, pp.
3775-3776 (1965)
Stewart et al. (Stewart), “All-D-Bradykinin and the problem of peptide
antimetabolites,” Nature, Vol. 206, pp. 619-620 (1965)
Vogler et al. (Volger), “Synthese von All-D-Val5-Angioteinsin II-Asp1-β-Amid1,”
Fasciculus 6, Vol. 48, No. 152, pp.1407-1414 (1965)
Fassina et al. (Fassina), “Recognition properties of peptides hydropathically
complementary to residues 356-375 of the c-raf protein,” J Biol. Chem., Vol. 264,
No. 19, pp. 11252-11257 (1969)
Wlodawer et al. (Wlodawer), “Conserved folding in retroviral proteases: Crystal
structure of a synthetic HIV – 1 protease,” Science, Vol. 245, pp.616-621 (1989)
Zawadzke et al. (Zawadzke), “A Racemic Protein,” J. Am. Chem. Soc., Vol. 114,
pp. 4002-4003 (1989)
Bessalle et al. (Bessalle), “All-D-magainin: chirality, antimicrobial activity and
proteolytic resistance,” FEBS, Vol. 274, No. 1,2, pp.151-155 (1990)
Wade et al. (Wade), “All-D amino acid-containing channel-forming antibiotic
peptides,” Proc. Natl. Acad. Sci. USA, Vol. 87, pp. 4761-4765 (1990)
The reference relied upon by appellants is:
Saint-Martin et al. (Saint-Martin), “Hydrogen production and deuterium-proton
exchange reactions catalyzed by Desulfovibrio nickel(II)-substituted rubredoxins,”
Proc. Natl. Acad. Sci., USA, Vol. 85, pp. 9378-80 (1988)
GROUND OF REJECTION
Claims 1-8 stand rejected under 35 U.S.C. § 103 as being unpatentable
over Zawadzke, Stewart, Wade, Vogler, Flouret, Fassina and Bessalle in view of
Wlodawer.1
1 We note the examiner’s reliance on Jung, “Proteins from the D-Chiral World,” Angew. Chem.
Int. Ed. Engl., Vol. 31, No. 11, pp. 1457-1459 (1992), and Petsko, “On the Other Hand . . . ,”
Science, Vol. 256, pp. 1403-1404 (1992). Answer, page 18. These references, however, were
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