Appeal No. 2001-1044 Page 2
Application No. 08/881,216
in free base form or acid addition salt form, encapsulated in
liposomes, which composition contains phospholipid components
which are selected from 1) palmitoyl-oleyl-phosphatidyl-choline, 2)
dioleoyl-phosphatidyl-glycerol, 3) dioleoyl-phosphatidyl-serine, 4) a
mixture of palmitoyl-oleyl-phosphatidyl-choline and palmitoyl-oleyl-
phosphatidyl-glycerol, 5) dimyristoyl-phosphatidyl-choline, or 6) a
mixture of dimyristoyl-phosphatidyl-choline and dimyristoyl-
phosphatidyl-glycerol.
23. A composition of claim 18 comprising phosphatidylethanolamine-
polyethyleneglycol.
24. A method for the treatment of fungal infections comprising topically
administering an antifungally effective amount of a composition of
claim 18 to a subject in need of such treatment.
25. A method of claim 24 for the treatment of pulmonary fungal
infections comprising administering an antifungally effective amount
of said composition to the lungs of a subject in need of such
treatment.
26. A composition of claim 18 which is in lyophilized form comprising as
cryoprotectant a disaccharide selected from sucrose, lactose,
mannitol, and maltose, or a monosaccharide selected from
fructose, glucose, galactose, mannose, xylit, and sorbit.
The examiner relies on the following references:
Lopez-Berestein et al. 4,812,312 Mar. 14, 1989
(Lopez-Berestein)
Janoff et al. (Janoff) 4,891,208 Jan. 02, 1990
Woodle et al. (Woodle) 5,013,556 May 07, 1991
Knight et al. (Knight) 5,049,388 Sep. 17, 1991
Crowe et al. (Crowe) WO 86/03938 Jul. 17, 1986
Birnbaum, “Pharmacology of the allylamines,” Journal Amer. Acad. Dermatol.,
Vol. 23, no. 4/ Part 2, Suppl., pp. 782-785 (1990)
Claims 25 and 26 stand rejected under 35 U.S.C. § 112, second
paragraph, as indefinite.
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