Ex Parte HOLTON et al - Page 4


                 Appeal No. 2001-1240                                                         Page 4                    
                 Application No. 08/374,520                                                                             

                 “hydrogen, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, hydroxy, protected hydroxy,                   
                 or together with R1 forms a carbonate.”  In the structures shown in the claims of                      
                 the ‘726 and ‘449 patents, by contrast, the positions corresponding to R14 and                         
                 R14a can only be hydrogens.                                                                            
                        Thus, a baccatin III derivative having an alkyl group at positions R14 and                      
                 R14a, or a method of making such a derivative, would infringe the instantly                            
                 pending claims without infringing the claims of the ‘726 and ‘449 patents.  This                       
                 single difference, while not the only difference between the pending and patented                      
                 claims, is enough in itself to defeat a rejection for “same invention” double                          
                 patenting.  The rejections under 35 U.S.C. § 101 are reversed.                                         
                 2.  The “new matter” rejection                                                                         
                        The examiner rejected product claims 45-56 under 35 U.S.C. § 112, first                         
                 paragraph, as “being new matter.”  Examiner’s Answer, page 4.  He explained                            
                 that “[t]he scope of the claims 45 to 56 is broader than the scope of the original                     
                 claims which required additional search and/or consideration.”  Id.  Later in the                      
                 Examiner’s Answer, the examiner elaborated on the prosecution history of claims                        
                 45-56:                                                                                                 
                        Prior to the first Office action, the compound claims are claims 5 to                           
                        8, 25 to 28 with a certain scope.  After the first Office action,                               
                        appellants canceled  claims 5 to 8, 25 to 28 and replaced them with                             
                        the instant claims 45 to 56 (on appeal) with a scope broader than                               
                        the scope of the original claims 5 to 8 and 25 to 28.  The new                                  
                        claims embody various species which are not enabled by the                                      
                        specification such as R6 and R6a are not hydrogen; R7, R7a, R9, R9a,                            
                        R10, R10a are hydrogen; R14 and R14a are not hydroxy.                                           
                 Page 6.                                                                                                






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