Appeal No. 2001-1263 Page 5
Application No. 08/475,955
7. The epitopes of claim 1 in combination with a pharmaceutical carrier for
administration to a patient.
8. The epitopes of claim 7 in an effective concentration for administration to a
patient to neutralize circulating autoantibody.
9. The epitopes of claim 7 further comprising a pharmaceutical carrier for
administration to a patient, wherein the carrier and concentration of sequences elicit an
immune response when administered to a host.
The references relied upon by the examiner are:
Colman, “Effects of amino acid sequence changes on antibody-antigen interaction.”
Research in Immunology, Vol. 145, pages 33-36, 1994.
Wraith et al. (Wraith), “Antigen recognition in autoimmune encephalomyelitis and the
potential for peptide-mediated immunotherapy.” Cell, Vol. 59, pages 247-255, 1989.
Tisch et al. (Tisch), “Antigen specific immunotherapy: is it a real possibility to combat
T-cell-mediated autoimmunity?” Proc. Natl. Acad. Sci. USA, Volume 91, pages 437-38,
1994.
Kaliyuperumal et al. (Kaliyuperumal), “Nucleosomal peptide epitopes for nephritis-
inducing T helper cell of murine lupus. J. Exp. Med., Vol. 183, pages 2459-69, 1996.
Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 Next
Last modified: November 3, 2007