Ex parte KUO et al. - Page 6


                  Appeal No.  2001-1392                                                           Page 6                     
                  Application No.  08/900,586                                                                                

                                 Most if not all inventions arise from a combination of old                                  
                         elements. … Thus, every element of a claimed invention may often be                                 
                         found in the prior art. … However, identification in the prior art of each                          
                         individual part claimed is insufficient to defeat patentability of the                              
                         whole claimed invention. … Rather, to establish obviousness based                                   
                         on a combination of the elements disclosed in the prior art, there must                             
                         be some motivation, suggestion or teaching of the desirability of                                   
                         making the specific combination that was made by the applicant.                                     
                         [Citations omitted].                                                                                
                         On reflection, the examiner has at best established that individual parts of the                    
                  claimed invention were known in the prior art.  What is missing, however, is                               
                  evidence that a skilled artisan, with no knowledge of the claimed invention, would                         
                  select the elements from the cited prior art references for combination in the manner                      
                  claimed.  “[A] rejection cannot be predicated on the mere identification … of                              
                  individual components of claimed limitations.  Rather particular findings must be                          
                  made as to the reason the skilled artisan, with no knowledge of the claimed                                
                  invention, would have selected these components for combination in the manner                              
                  claimed.”  Ecolochem Inc. v. Southern California Edison, 227 F.3d 1361, 1375, 56                           
                  USPQ2d 1065, 1075-76 (Fed. Cir. 2000).                                                                     
                         Thus we find the examiner has failed to provide sufficient evidence to support                      
                  a prima facie case of obviousness of a method of determining the concentration of                          
                  an analyte in a sample that uses the ratio of control analytes to normalize the                            
                  concentration of a specific target analyte.  We also find that the examiner fails to                       
                  provide appropriate evidence that a test matrix having the attendant structure                             
                  required by step a) of claim 1, would have been prima facie obvious to a person of                         
                  ordinary skill in the art at the time the invention was made.  We note that the                            






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