Ex Parte PILLAI et al - Page 7


                     Appeal No. 2001-1779                                                                                                           
                     Application No. 09/398,898                                                                                                     


                     necessarily have the required estrogenic activity.  Anticipation is not established                                            
                     by picking and choosing isolated elements from unrelated portions of a reference                                               
                     and combining them to arrive at the claimed invention.  See In re Arkley,                                                      
                     455 F.2d 586, 587-588, 172 USPQ 524, 526 (CCPA 1972).  We reverse the                                                          
                     anticipation rejection of claim 2 over US  ‘926.                                                                               
                                                                                                                                                   
                                                        Discussion – Obviousness                                                                    
                              Claim 2 stands rejected by the examiner under 35 U.S.C. § 103(a) as                                                   
                     being unpatentable “over either WO ‘069 or US ‘926, each in view of the other.”                                                
                     Examiner’s Answer, page 4.  The examiner’s rationale for holding claim 2                                                       
                     obvious is set forth at page 4 of the Examiner’s Answer as follows:                                                            
                                       WO ‘069 and US ‘926 teach all of the limitations of the claim                                                
                              as stated above.  Neither reference specifically teaches the amount                                                   
                              of extract needed to achieve estrogenic activity at least equivalent                                                  
                              to 1 nM of estradiol.  It is within the skill of the art to determine the                                             
                              amount of active agent needed to achieve a beneficial and/or                                                          
                              therapeutic effect.  Therefore, absent evidence of unexpected                                                         
                              results, no patentable weight is given to the claimed amount of                                                       
                              chickpea extract.  It would have been obvious to one of ordinary                                                      
                              skill in the art at the time of the invention to combine the teachings                                                
                              of WO ‘069 and US ‘926 with the reasonable expectation of                                                             
                              producing a topical composition that exhibits estrogenic activity.                                                    
                              We do not find the examiner’s reasoning persuasive of obviousness.  The                                               
                     criteria for obviousness determinations are set forth in Graham v. John Deere                                                  
                     Co., 383 U.S. 1, 17-18, 148 USPQ 459, 467 (1966) as follows:                                                                   
                              [T]he scope and content of the prior art are to be determined; differences                                            
                              between the prior art and the claims at issue are to be ascertained; and                                              
                              the level of ordinary skill in the pertinent art resolved.  Against this                                              
                              background, the obviousness or nonobviousness of the subject matter is                                                

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