Ex Parte FISCHETTI - Page 7


                 Appeal No.  2001-2524                                                        Page 7                  
                 Application No.  08/369,295                                                                          
                               analyzed – not in a vacuum, but always in light of the                                 
                               teachings of the prior art and of the particular                                       
                               application disclosure as it would be interpreted by                                   
                               one possessing the ordinary level of skill in the                                      
                               pertinent art.                                                                         
                        See also In re Geerdes, 491 F.2d 1260, 1262, 180 USPQ 789, 791                                
                 (CCPA 1974) (“Before considering the rejections under 35 U.S.C. § … 112, we                          
                 must first decide … [what] the claims include within their scope.”).  Appellant’s                    
                 claims require that the antigen conjugate elicit a protective immune response to                     
                 streptococcal infection in a mammal when administered mucosally.  As the                             
                 examiner recognizes (Paper No. 38, page 3) appellant’s specification exemplifies                     
                 the carrier cholera toxin B (CTB).  The specification also discloses (page 25),                      
                 “[t]hose skilled in the art will recognize that other carriers can be employed …                     
                 [including] the E. coli labile toxin B subunit or the pili from E. coli cells identified             
                 as K99 pili and 987 pili….”                                                                          
                        While the examiner may be concerned that the claims include inoperative                       
                 embodiments, as set forth in Atlas Powder Co. v. E.I. DuPont De Nemours &                            
                 Co., 750 F.2d 1569, 1576-77, 224 USPQ 409, 414 (Fed. Cir. 1984):                                     
                               Even if some of the claimed combinations were inoperative,                             
                               the claims are not necessarily invalid.  “It is not a function of                      
                               the claims to specifically exclude ... possible inoperative                            
                               substances....”  In re Dinh-Nguyen, 492 F.2d 856, 859-59,                              
                               181 USPQ 46, 48 (CCPA 1974)(emphasis omitted).  Accord,                                
                               In re Geerdes, 491 F.2d 1260, 1265, 180 USPQ 789, 793                                  
                               (CCPA 1974); In re Anderson, 471 F.2d 1237, 1242, 176                                  
                               USPQ 331, 334-35 (CCPA 1971).  Of course, if the number                                
                               of inoperative combinations becomes significant, and in                                
                               effect forces one of ordinary skill in the art to experiment                           
                               unduly in order to practice the claimed invention, the claims                          
                               might indeed be invalid.  See e.g., In re Cook, 439 F.2d 730,                          
                               735, 169 USPQ 298, 302 (CCPA 1971).                                                    







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