Ex Parte MEISEL et al - Page 5


                 Appeal No.  2002-0438                                                        Page 5                   
                 Application No. 09/181,671                                                                            

                        The rejection of record does not meet the above criteria.  Dieter, while                       
                 teaching the compound that is the subject of the claims is known, does not teach                      
                 or suggest that the compound has different crystalline structures.  Thus, the                         
                 rejection of record does not set forth any motivation to combine Dieter with                          
                 Kirk-Othmer because, although Kirk-Othmer does teach that it is known that                            
                 crystal polymorphism is known generally to exist, there is no teaching or                             
                 suggestion in the references that the compound of the claimed invention is                            
                 known to exhibit such polymorphism.                                                                   
                        Moreover, the record demonstrates that the compound as prepared by the                         
                 prior art is a mixture of crystal polymorphs, whereas appellants have succeeded                       
                 in isolating thee distinct polymorphs, i.e., Modifications A, B and C.  See                           
                 Declaration of Wilfried Thiel, Paper No. 9.  Thus, the isolated crystal polymorphs                    
                 as claimed in the instant application do not appear to be an inherent property of                     
                 the claimed compound as disclosed by the prior art of record.                                         





















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