Ex Parte USMAN et al - Page 9


                  Appeal No. 2002-1251                                                              Page 9                     
                  Application No. 08/459,340                                                                                   

                  accurate.  First, most of Branch is directed antisense therapy, not ribozymes.  In                           
                  addition, although the examiner focuses on problems relating to delivery of                                  
                  ribozymes in vivo, Branch’s focus is on the difficulty involved in choosing an                               
                  appropriate target site in a substrate RNA.  To the extent that ribozyme target                              
                  selection is relevant to the instant claims, it would seem to relate more to the                             
                  scope of claims such as claim 74, which recites no structural limitations on the                             
                  design of the recited nucleozyme, rather than, as the examiner would have it, to                             
                  delivery of ribozymes in vivo.  Branch does not state that delivery of ribozymes in                          
                  vivo is problematic and therefore does not provide evidence to support the                                   
                  examiner’s position.                                                                                         
                          Finally, “[i]t is axiomatic that, in proceedings before the PTO, claims in an                        
                  application are to be given their broadest reasonable interpretation consistent                              
                  with the specification.”  In re Sneed, 710 F.2d 1544,1548, 218 USPQ 385, 388                                 
                  (Fed. Cir. 1983).  Terms appearing in the preamble of a claim do not necessarily                             
                  limit the scope of the claim.  See IMS Technology, Inc. v. Haas Automation, Inc.,                            
                  206 F.3d 1422, 1434, 54 USPQ2d 1129, 1137 (Fed. Cir. 2000) (“If the preamble                                 
                  adds no limitations to those in the body of the claim, the preamble is not itself a                          
                  claim limitation and is irrelevant to proper construction of the claim.”).                                   
                          Here, the claims are directed to a “pharmaceutical composition”                                      
                  comprising a nucleozyme and a pharmaceutically acceptable carrier.  See, e.g.,                               
                  claim 74.  The preamble does not add any limitations to those appearing in the                               
                  body of the claim and therefore does not further limit the claim.  According to the                          
                  broadest reasonable interpretation, therefore, the claims read on any                                        





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