Appeal No. 1998-1893 Application 08/088,125 technical reasoning in support of this argument, and the examiner’s mere speculation is not a sufficient basis for a prima facie case of obviousness. See In re Warner, 379 F.2d 1011, 1017, 154 USPQ 173, 178 (CCPA 1967), cert. denied, 389 U.S. 1057 (1968); In re Sporck, 301 F.2d 686, 690, 133 USPQ 360, 364 (CCPA 1962). For this reason and because the examiner has not explained how the other applied references remedy this deficiency in Macpherson, the METHOCEL references and Wittwer (answer, page 9), we reverse the rejection of claim 18 and claims 19, 21, 24, 26 and 27 which depend therefrom. Claim 20 Claim 20 is a product-by-process claim. Hence, the patentability of the claimed invention is determined based on the product itself, not on the method of making it. See In re Thorpe, 777 F.2d 695, 697, 227 USPQ 964, 966 (Fed. Cir. 1985) (“If the product in a product-by-process claim is the same as or obvious from a product of the prior art, the claim is unpatentable even though the prior art product was made by aPage: Previous 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 NextLast modified: November 3, 2007