Ex parte BURMEISTER et al. - Page 4




          Appeal No. 1999-1959                                       Page 4           
          Application No. 08/881,586                                                  


          platinum coil 19 is fitted over the distal end portion 21 of                
          the wire 18.  The core wire and platinum coil are enclosed in               
          a sleeve 32, 34 of plastic material.  The sleeve surrounding                
          the De Toledo core wire comprises two sleeves 32, 34 having a               
          coupling sleeve between their opposed ends.   The examiner and              
          appellants agree that De Toledo discloses a guide wire as                   
          recited in claim 28 with the exception of the radiopaque                    
          material being incorporated within the distal jacket portion.               
               Miyano teaches two alternatives for providing a guide                  
          wire having a core enclosed within a plastic layer with X-ray               
          contrast characteristics.  The first alternative is to fix a                
          member made of radiopaque material to the front terminal of                 
          the distal portion 2b of the core 2 (Figure 1).  The second                 
          alternative (Figure 2) is to mix pulverized X-ray contrast                  
          material with the polymer material forming the base of a layer              
          4 surrounding the core.  Miyano points out that, as a result                
          of the invention disclosed therein,                                         
               the position of the overall body of the guide wire                     
               can be easily confirmed under the X-ray contrast.                      
               In particular, the position of the front portion of                    
               the guide wire can be easily confirmed [page 7].                       

               In light of the teachings of Miyano, the examiner                      
          contends that it would have been obvious to one of ordinary                 





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