Appeal No. 1999-1959 Page 4 Application No. 08/881,586 platinum coil 19 is fitted over the distal end portion 21 of the wire 18. The core wire and platinum coil are enclosed in a sleeve 32, 34 of plastic material. The sleeve surrounding the De Toledo core wire comprises two sleeves 32, 34 having a coupling sleeve between their opposed ends. The examiner and appellants agree that De Toledo discloses a guide wire as recited in claim 28 with the exception of the radiopaque material being incorporated within the distal jacket portion. Miyano teaches two alternatives for providing a guide wire having a core enclosed within a plastic layer with X-ray contrast characteristics. The first alternative is to fix a member made of radiopaque material to the front terminal of the distal portion 2b of the core 2 (Figure 1). The second alternative (Figure 2) is to mix pulverized X-ray contrast material with the polymer material forming the base of a layer 4 surrounding the core. Miyano points out that, as a result of the invention disclosed therein, the position of the overall body of the guide wire can be easily confirmed under the X-ray contrast. In particular, the position of the front portion of the guide wire can be easily confirmed [page 7]. In light of the teachings of Miyano, the examiner contends that it would have been obvious to one of ordinaryPage: Previous 1 2 3 4 5 6 7 8 9 10 11 12 NextLast modified: November 3, 2007