Ex Parte BROWN et al - Page 4


                  Appeal No.  2001-0624                                                 Page       4                     
                  Application No.  08/204052                                                                                

                         While the Brief addresses the second issue, it does not appear to address                          
                  the first.  Stated differently, the brief does not contain arguments of the                               
                  appellants with respect to each of the issues presented for review in 37 CFR                              
                  § 1.192(c)(6), and the basis therefore, with citations of the authorities, statutes,                      
                  and parts of the record relied on as required by 37 CFR § 1.192(c)(8).  As set                            
                  forth in 37 CFR § 1.192(d) “if a brief is filed which does not comply with all the                        
                  requirements of paragraph (c), the appellant will be notified of the reasons for                          
                  noncompliance.”  On this record, appellants were not so notified.  Accordingly,                           
                  we remand the application to the examiner to take appropriate action.                                     
                                                    OTHER ISSUES                                                            
                         While we take no action on the merits of this appeal, we make the                                  
                  following observations:                                                                                   
                         There are several instances in the Answer where the examiner makes an                              
                  unsupported finding of fact.  See e.g., Answer, page 4 “[i]t is well known in the art                     
                  that there are certain integral aspects to making and using a transgenic mouse”;                          
                  Answer, page 5, “the art teaches that ALS … is associated with certain mutated                            
                  SOD-1 polypeptides.”  Upon further prosecution, we encourage the examiner to                              
                  support her findings of fact with appropriate evidence.  Findings of fact, as well                        
                  as the conclusions of law, must be made in accordance with the Administrative                             
                  Procedure Act, 5 U.S.C. 706 (A), (E) (1994). See Zurko v. Dickinson, 527 U.S.                             
                  150, 158, 119 S.Ct. 1816, 1821, 50 USPQ2d 1930, 1934 (1999).                                              









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