Ex Parte NIJKERK et al - Page 6



             Appeal No. 2001-1162                                                           Page 6               
             Application No. 08/726,803                                                                          
             any individual reference are to be combined with the disclosure of another reference, it            
             is unclear why the examiner believes the subject matter of any claim on appeal would                
             have been obvious from a consideration of Buchs as a so-called primary reference.  To               
             the extent the examiner's rejection under 35 U.S.C. § 103 is premised upon a                        
             combination of references using Buchs as a so-called primary reference, such a                      
             rejection is reversed.                                                                              
                   It cannot be gainsaid that Mueller describes sodium folinate solutions.  See, e.g.,           
             Example 4.  However, the examiner has not explained, and it is not apparent from                    
             reading Mueller, how Mueller in and of itself teaches, suggests, or motivates one of                
             ordinary skill in the art to formulate the sodium folinate solutions of that reference in the       
             manner required by the claims on appeal.  The examiner has not pointed to any                       
             passage of Mueller, nor do we find any, which suggests that the sodium folinate                     
             solutions of that reference should be used in combination with sodium citrate, sodium               
             acetate or mixtures thereof, or for that matter, any stabilizer.  To the extent the                 
             examiner's rejection is premised upon the use of Mueller as a so-called primary                     
             reference, any such rejection under 35 U.S.C. § 103 is reversed.                                    
                   The examiner’s reliance upon Remington’s and Hagers is unavailing as these                    
             references do not provide the needed reason, suggestion or motivation to use sodium                 
             citrate or sodium acetate in compositions which consist essentially of or consist of                
             sodium folinate.                                                                                    
                   We are aware that applicants rely upon a declaration filed under 37 CFR § 1.132               
             by J.J. Scherpbier.  However, since we have determined that the references relied upon              







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