Ex Parte ZOLTEWICZ et al - Page 2


                 Appeal No.  2001-1294                                                          Page 2                  
                 Application No.  08/473,667                                                                            
                        Leeson               4,965,074                   Oct. 23, 1990                                 
                 (Tu), William R. Kem, Worm Toxin in 3 HANDBOOK OF NATURAL TOXINS 353-60                                
                 (Anthony T. Tu ed., Marcel Dekker, New York, 1988)                                                     
                 Meyer et al. (Meyer), “Effects of Nucleus Basalis Lesions on the Muscarinic and                        
                 Nicotinic Modulation of [3H]Acetycholine Release in the Rat Cerebral Cortex,”                          
                 J. Neurochemistry, Vol. 49, pp. 1758-62 (1987)                                                         
                 Kem et al. (Kem), “Differential Actions of Anabaseine and its 3 DMAB Adduct                            
                 Upon Brain and Neuromuscular Nicotinic Receptor,” Biosis Abstr., No. 42075229                          
                 (1991)                                                                                                 
                 Swanson et al. (Swanson), Nicotinic Acetylcholine Receptor Function Studied                            
                 with Synthetic(+)-Anatoxin-a and Derivatives in MARINE TOXINS ORIGIN,                                  
                 STRUCTURE, AND MOLECULAR PHARMACOLOGY 107-17 (Sherwood Hall et al. eds.,                               
                 American Chemical Society, Washington, DC, 1990)                                                       
                 (Rawlins), BENTELY’S TEXTBOOK OF PHARMACEUTICS 16 (E. A. Rawlins ed.,                                  
                 8th ed., Bailliere Tindall, London 1978)                                                               
                 (Remington), REMINGTON’S PHARMACEUTICAL SCIENCE, 1691-92 (A. Oslo                                      
                 ed., 17th ed., Mack, Easton PA 1985)                                                                   

                                             GROUND OF REJECTION                                                        
                        Claims 9 and 25-32 stand rejected under 35 U.S.C. § 103.  As evidence                           
                 of obviousness the examiner relies on the combination of Tu, Meyer, Kem1,                              
                 Remington, Rawlins and/or Swanson and Leeson.2                                                         
                        We reverse.                                                                                     
                                                    DISCUSSION                                                          



                                                                                                                        
                 1 According to the examiner (Answer, page 6), “the Kem (1991) reference … [was] published after        
                 the very first filing date….”  Therefore, Kem appears to have been improperly applied in the           
                 examiner’s rejection.  Nevertheless, the examiner finds that Kem was merely cumulative to the          
                 teachings of Meyer.  (Answer, bridging paragraph, pages 6-7).  Accordingly we will not consider        
                 Kem in our deliberations.                                                                              
                 2 We recognize that in the Final Office Action the examiner set forth three separate rejections        
                 under 35 U.S.C. § 103.  For administrative convenience we have consolidated all three rejections       
                 into one ground of rejection.                                                                          





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