Ex Parte EVANS et al - Page 2


                 Appeal No.  2001-1411                                                           Page 2                   
                 Application No.   08/966,876                                                                             
                            a ligand for a member of the steroid/thyroid superfamily of receptors,                        
                            effective to ameliorate the symptoms of said neoplastic disease                               
                         wherein said inhibitor is not sodium butyrate.                                                   

                         The references relied upon by the examiner are:                                                  
                 Evans et al. (Evans) 2              6,387,673                   May 14, 2002                            
                 Morioka et al. (Morioka)            JP 60149520 A                August 7, 1985                          
                                                                                                                         
                 Chen et al. (Chen), “Retinoic Acid is Required for and Potentiates Differentiation                       
                 of Acute Promyelocytic Leukemia Cells by Nonretinoid Agents,” Blood, Vol. 84,                            
                 No. 7, pp. 2122-2129 (1994)                                                                              
                 Taunton et al. (Taunton), “A Mammalian Histone Deacetylase Related to the                                
                 Yeast Transcriptional Regulator Rpd3p,” Science, Vol. 272, pp. 408-411 (1996)                            
                                             GROUNDS OF REJECTION                                                         
                         Claims 1, 3-15, 17 and 18 stand rejected under 35 U.S.C. § 103 as                                
                 obvious over Chen in view of Taunton and Morioka.                                                        
                         Claims 1 and 5 stand rejected under the judicially created doctrine of                           
                 obviousness-type double patenting as being unpatentable over claims 1-6 of                               
                 Evans.                                                                                                   
                         We reverse the rejection under 35 U.S.C. § 103 and affirm the rejection                          
                 under the judicially created doctrine of obviousness-type double patenting.                              








                                                                                                                          
                 2 The Answer refers to Application No. 08/846,881, instead of the Patent No. of the Evans patent.        
                 We note, however, that Evans was not issued at the time the Answer was written.  Given the               
                 issuance of the Evans patent the obviousness-type double patenting rejection which relies on             
                 Evans is no longer provisional.                                                                          





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