Ex Parte MUEHL - Page 2



               Appeal No.  2001-2011                                                                         Page 2                   
               Application No. 08/402,413                                                                                             
                       Claims 1 through 3 are drawn to “benzothiophene compounds substituted at the                                   
               6-position, with a bridging group at the 3-position, and having a basic side chain.”  Brief,                           
               page 3.  In view of its brevity, we reproduce the examiner’s rejection in its entirety                                 
               (except that, for the sake of clarity, we have substituted a single name for a reference                               
               wherever the examiner has used more than one name for the same reference):                                             
                       Kennedy [ ], Descamps [‘204, Descamps ‘707] and Pestellini are                                                 
                       references in the same field of anti-angina/anti-arrhythmia compounds.                                         
                       Kennedy [d]isclosed compounds having a protected hydroxy or                                                    
                       alkoxymethylene chain between the benzothi[o]nyl moiety and the phenyl                                         
                       moiety.  The combined teachings of Descamps ‘204, [Descamps] ‘707                                              
                       and Pestellini [ ] placed the following teaching in the possession of the                                      
                       artisan that:                                                                                                  
                               1) the benzofuranyl ring system and benzothi[o]nyl ring system are                                     
                       interchangeable for such compounds (see [Descamps] ‘204 vs                                                     
                       [Descamps] ‘707:                                                                                               
                               2) the linkage between the bicyclic ring system and the phenyl ring                                    
                       can be CO or substituted alkylene (see [Descamps] ‘204 v [Kennedy],                                            
                       linkage at 3-position, see [Kennedy] p. 7 formula XV, XVI and p. 9 formula                                     
                       XX.                                                                                                            
                               3) the position isomers also have the expected similar activity (see                                   
                       Pestellini);                                                                                                   
                               4) the substituents on the linking alkylene chain can be hydroxy,                                      
                       alkoxy, acylated hydroxy, amino, mono- or di-alkylamino (see [Pestellini’s]                                    
                       linking group);                                                                                                
                               5) the “other substituent on the bicyclic ring system can be alkyl,                                    
                       cyclohexyl, or phenyl[.]                                                                                       
               Answer, pages 4 and 5.                                                                                                 
                       Noticeably missing from this disjointed series of conclusions is a coherent                                    










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