Appeal No. 2001-2347
Application No. 08/251,574
Claim 1 is representative of the claims on appeal and reads as follows:
1. A conjugate, comprising an antibody directed toward a cell surface associated
antigen, wherein said antigen is selected from the group consisting of 15A8 antigen and
ZME-018 antigen; and a biological response modifier moiety, wherein said moiety is
selected from the group consisting of TNF-alpha, TNF-beta and Interleukin-1.
The references relied upon by the examiner are:
Rodwell et al. (Rodwell) 4,671,958 June 9, 1987
Huston et al (Huston) WO 88/09344 Dec. 1, 1988
PCT Publication
Hudziak et al. (Hudziak) WO 89/06692 July 27, 1989
PCT Publication
Zimmerman (Zimmerman) EP 281070 Sept. 7, 1988
European Patent
Houston et al. (Houston) EP 256714 Feb. 24, 1988
European Patent
White et al. (White), “Two Monoclonal Antibodies Selective for Human Mammary
Carcinoma,” Cancer Research, Vol 45, pp. 1337-1343 (1985)
Shultz et al. (Shultz), “Monoclonal Antibody-Directed Effector Cells Selectively Lyse
Human Melanoma Cells In Vitro and In Vivo,” Proc. Natl. Acad. Sci., Vol 80, pp. 5407-
5411 (1983)
Claim Grouping
According to appellants, the claims stand or fall together. Brief, page 6. We
decide this appeal on the basis of claim 1, as representative of the claims before us.
In Young, 927 F.2d 588, 590, 18 USPQ2d 1089, 1091 (Fed. Cir. 1991).
Grounds of Rejection
2
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