Ex Parte ROLLINS et al - Page 6


                Appeal No. 2001-2394                                                  Page 6                  
                Application No. 08/437,306                                                                    

                indefinite, but “[w]hen a word of degree is used the [fact-finder] must determine             
                whether the patent’s specification provides some standard for measuring that                  
                degree.”  Seattle Box Co. v. Indus. Crating & Packaging, Inc., 731 F.2d 818, 826,             
                221 USPQ 568, 574 (Fed. Cir. 1984).                                                           
                      In this case, claim 5 recites a “DNA comprising a sequence of nucleotide                
                bases the same or essentially the same as SEQ ID NO:1.”  The specification                    
                does not expressly define what degree of similarity is shared by sequences that               
                are “essentially the same.”  In fact, as far as we can tell, the specification does           
                not use the phrase “essentially the same” at all.  The closest comparable phrase              
                seems to be “substantially the same,” which is also left undefined.  See page 3               
                (“Another aspect of the invention includes DNA sequences coding on expression                 
                for a human JE polypeptide.  One such DNA sequence is the same or                             
                substantially the same as the approximately 772 nucleotide sequence which                     
                appears below in Table I.”).  Thus, the specification provides no standard to                 
                measuring the degree of sequence similarity required by the claim term                        
                “essentially the same” and we agree with the examiner that claims 5-8, 25-27,                 
                and 29-35 are indefinite on that basis.                                                       
                      Appellants argue that court cases and issued patents support their                      
                position that terms like “substantially” and “essentially” are not indefinite.  See the       
                Appeal Brief, pages 8-10.  Appellants also take issue with the examiner’s                     
                position, from earlier in prosecution, that sequences could be considered                     









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