Ex Parte CHO et al - Page 2


                 Appeal No. 2001-2646                                                         Page 2                    
                 Application No. 08/463,951                                                                             

                 the examiner has indicated that these claims would be allowable if rewritten in                        
                 independent form.  See Paper No. 18, mailed June 16, 2000, page 4.                                     
                        Claims 58 and 61 are representative of the subject matter on appeal are                         
                 reproduced in the attached appendix.                                                                   
                        The examiner relies on the following references:                                                
                 Cho et al. (‘009)                 5,530,009                   Jun. 25, 1996                          
                 Rouissi et al. (Rouissi), “Selectivity and Specificity of New, Non-peptide,                            
                 Quinuclidine Antagonists of Substance P,” Biochemical and Biophysical                                  
                 Research Communications, Vol. 176, No. 2, pp. 894-901 (1991)                                           
                 Kucharczyk et al. (Kucharczyk), “Tetrapeptide Tachykinin Antagonists:  Synthesis                       
                 and Modulation of the Physicochemical and Pharmacological Properties of a                              
                 New Series of Partially Cyclic Analogs,” J. Med. Chem., Vol. 36, pp. 1654-1661                         
                 (1993)                                                                                                 
                 Maggi et al. (Maggi), ”Tachykinin receptors and tachykinin receptor antagonists,”                      
                 J. Auton. Pharmacol., Vol. 13, pp. 23-93 (1993)                                                        
                        Claims 7-10, 12, 14, 16, 18, 20, 21, 28-42, 49-59, 61, 62, 64, and 65 stand                     
                 rejected under 35 U.S.C. § 112, first paragraph, as nonenabled.                                        
                        Claims 7-9, 20, 21, 28-30, 36, 39, 49-51, 57-59, 61, 62, 64, and 65 stand                       
                 rejected for obviousness-type double patenting over the claims of U.S. Patent                          
                 5,530,009.                                                                                             
                        We affirm the rejection for obviousness-type double patenting and reverse                       
                 the rejection for nonenablement.                                                                       
                                                     Background                                                         
                        Tachykinins are a family of peptides that share a common amidated                               
                 carboxy-terminal sequence.  See the specification, page 1.  “Tachykinins are                           
                 widely distributed in both the central and peripheral nervous systems, are                             





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