Ex Parte MAJEED et al - Page 4




            Appeal No. 2002-0454                                                                              
            Application No. 09/083,122                                                                        
                   The examiner acknowledges that Lewis does not teach the process involved in                
            combining extracts at pH10, refluxing the treated extract to obtain potassium hydroxy             
            citrate, milling, sifting, blending, and packing the dried potassium hydroxycitric acid           
            under nitrogen.  Id.                                                                              
                   The examiner relies on Lowenstein for its disclosure of a method of obtaining              
            hydroxycitric acid from the Garcinia acid lactone by base hydrolysis with potassium               
            hydroxide with heating followed by acidification.  Lowenstein, column 1, lines 35-39;             
            Answer, page 4.  The examiner argues the heating step is the equivalent of a refluxing            
            step.                                                                                             
                   “With respect to [the steps of] combining extracts at pH 10, refluxing the treated         
            extract to obtain potassium hydroxy citrate”, the examiner concludes “it would have               
            been quite obvious for one having an ordinary skill in the art to extract the dried fruit         
            rinds of Garcinia cambogia three times with ethanol to increase the quantity of the               
            extracted material; furthermore, Lowenstein, the editor of Lewis' work, teaches that the          
            hydroxy citric acid ... may be obtained from Garcinia by base hydrolysis, e.g. potassium          
            hydroxide with heating followed by acidification, which means that it would have been             
            obvious for the one with an ordinary skill in the art to have used Lowenstein’s process           
            without acidification in order to produce the non-hygroscopic potassium salts of                  
            hydroxycitric acid.”  Id.                                                                         





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