Ex Parte STEINEMANN et al - Page 5




             Appeal No. 2002-0869                                                                                
             Application No. 08/580,384                                                                          
             references Snyder and Howard, submitted with respect to the issue of expectation of                 
             success in the copending application to support their position with evidence.                       
                   In addition, appellants argue in the current record that Esmon does not teach the             
             presence of TNF in the ocular environment, and provides no evidence that the                        
             biochemical cascade of events associated with inflammation and TNF occurs in either                 
             the aqueous or vitreous humor of the eye.  Brief, page 9.  Upon return of the application           
             to the examiner, if the examiner determines it appropriate to maintain the obviousness              
             rejection in view of the currently cited references, the examiner should make of record             
             evidence confirming that the biochemical cascade of events associated with                          
             inflammation and TNF occurs in the eye.                                                             


                                                 CONCLUSION                                                      
                   We vacate the rejections of claims 22-27 under 35 U.S.C. § 103(a) for                         
             obviousness over Galin or Iverson in view of Bang and Esmon, and of claims 28-29                    
             under 35 U.S.C. § 103(a) for obviousness over Galin or Iverson in view of Bang and                  
             Esmon in further view of Stocker.  Upon return of the application, the examiner should              
             take a step back and review the record in copending appeal Serial No. 08/696,698                    
             (Appeal No. 2001-1685) with respect to the issue of expectation of success and other                
             matters consistent with the discussion herein.                                                      





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