Ex Parte HERRMANN et al - Page 19


                Appeal No. 2002-1630                                                 Page 19                  
                Application No. 09/175,713                                                                    

                aminooxypentane-modified chemokine would be the same as the polynucleotide                    
                encoding the unmodified chemokine.                                                            
                      On return of this application, the examiner should consider whether claim               
                1 is sufficiently definite to meet the requirements of 35 U.S.C. § 112, second                
                paragraph.  In addition, if a polynucleotide encoding an aminooxypentane-                     
                modified chemokine is, in fact, the same as a polynucleotide encoding an                      
                unmodified chemokine, the examiner should consider whether any of the claims                  
                are anticipated by prior art disclosing a chemokine-encoding polynucleotide.                  
                                                  Summary                                                     
                      We reverse the rejection for inadequate written description because the                 
                examiner has not adequately explained why those skilled in the art would not                  
                have recognized the specification’s description as showing that Appellants were               
                in possession of the invention now claimed.  We also reverse the rejection of                 
                claims 6-9 for nonenablement, because the examiner has not explained why                      
                undue experimentation would have been required to make and use fragments of                   
                the recited amino-terminal-modified chemokines, or variants encoded by                        
                polynucleotides that hybridize under stringent conditions.  However, we affirm the            
                rejection of claims 1-5, 10-14, 17, and 18 for nonenablement, because claim 5                 
                reads on amino-terminal-modified chemokines that vary from the recited                        
                chemokines in any way and to any degree, and the specification does not                       
                provide sufficient guidance to practice the very broad scope of this claim.                   
                Claims 1-4, 10-14, 17, and 18 fall with claim 5.                                              







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