Ex Parte Zhang et al - Page 3



           Appeal No. 2003-0061                                                                     
           Application No. 09/611,109                                                               

           and methylene has only two bonds, it is not possible to                                  
           substitute a methylene group with two oxo groups.                                        
                 It is noteworthy that appellants have not contested the                            
           examiner's reasoning.  Indeed, appellants agree with the examiner                        
           that "replacing 'N' for 'CH ' creates an inoperative embodiment"2                                                        
           (page 4 of Brief, second paragraph), and that a species                                  
           possessing two oxo groups "creating 6 bonds to carbon cannot                             
           exist" (page 7 of Brief, second paragraph).  In essence, it is                           
           appellants' argument that one of ordinary skill in the art would                         
           know that methylene groups cannot be replaced by N or with two                           
           oxo groups.  According to appellants, one of ordinary skill in                           
           the art would understand, in light of the specification and state                        
           of the prior art, that methylene is substituted by "N alkyl" or                          
           "NH," not N, and that only one oxo group can be optionally                               
           substituted for a methylene group.                                                       
                 Appellants' argument would be appropriate if the ground of                         
           rejection was under the first paragraph of 35 U.S.C. § 112, i.e.,                        
           appellants' argument addresses why one of ordinary skill in the                          











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