Ex Parte KEITH et al - Page 11



          Appeal No. 2003-1337                                                        
          Serial No. 08/480,411                                                       
          over the inner cured resin layer, and an outer cured resin                  
          layer (54) over and encasing the braid layer, wherein the braid             
          layer is woven in a weave having relatively fewer picks per inch            
          at the proximal end and relatively more picks per inch at the               
          distal end (col. 2, lines 31-34; col. 3, lines 22-30; col. 3,               
          line 66 - col. 4, line 37; col. 10, lines 13-14).                           
               The declaration under 37 CFR § 1.131 shows that, no later              
          than November 1992, the appellants were in possession of a                  
          microtube having an inner cured resin layer, a braid layer over             
          the inner cured resin layer, and an outer cured resin layer over            
          and encasing the braid layer, wherein the braid pick count varies           
          over the length of the catheter to provide increased flexibility            
          from the proximal end to the distal end (declaration exhibits B-            
          I).                                                                         
               The declaration exhibits do not show fewer picks per inch at           
          the proximal end than at the distal end.  However, given that the           
          pick count varies over the length of the catheter to provide                
          increased flexibility from the proximal end to the distal end, it           
          would have been obvious to one of ordinary skill in the art to              
          vary the pick count as needed to obtain the desired flexibility             
          increase from the proximal end to the distal end.                           
               The declaration under 37 CFR § 1.131, therefore, shows                 
          possession of subject matter which at least would have rendered             
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