Ex Parte HOLLIS et al - Page 1




                            The opinion in support of the decision being entered today was not written                   
                                   for publication and is not binding precedent of the Board.                            
                                                                                         Paper No. 31                    
                         UNITED STATES PATENT AND TRADEMARK OFFICE                                                       
                                                     __________                                                          
                               BEFORE THE BOARD OF PATENT APPEALS                                                        
                                             AND INTERFERENCES                                                           
                                                     __________                                                          
                                         Ex parte GREGORY F. HOLLIS, and                                                 
                                                  GEORGE E. MARK                                                         
                                                     __________                                                          
                                                Appeal No. 2003-1594                                                     
                                              Application No. 08/970,266                                                 
                                                     __________                                                          
                                                      ON BRIEF                                                           
                                                     __________                                                          
                 Before SCHEINER, MILLS, and GREEN, Administrative Patent Judges.                                        
                 GREEN, Administrative Patent Judge.                                                                     

                                               DECISION ON APPEAL                                                        
                        This is a decision on appeal under 35 U.S.C. § 134 from the examiner’s                           
                 final rejection of claims 10-25.  Claims 10 and 11 are representative of the                            
                 subject matter on appeal, and read as follows:                                                          
                     10. A method for expression of a recombinant antibody gene in NS/O                                  
                            cells, comprising:                                                                           
                            (a) transferring a vector into said cells, said vector comprising said                       
                                recombinant antibody gene and murine immunoglobulin gamma 2A                             
                                locus-specific DNA sequences for homologous recombination                                
                                targeting, wherein said recombinant antibody gene comprises a                            
                                nucleic acid encoding for a recombinant antibody and a promoter                          
                                transcriptionally coupled to said nucleic acid providing for                             
                                expression in said NS/O cells;                                                           






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