Appeal No. 2003-1745 2
Application No. 09/859,614
THE INVENTION
According to the appellants, the invention is directed to the use of a vasopeptidase
inhibitor to treat or slow the progression of cognitive dysfunction and treat and/or prevent
dementia. Additional limitations are described in the following illustrative claim.
THE CLAIMS
Claim 13 is illustrative of appellants’ invention and is reproduced below.
13. A method of treating and/or slowing the progression of the condition cognitive
dysfunction and treating and/or preventing the condition dementia consisting essentially of
administering to a patent an effective amount of the vasopeptidase inhibitor omapatrilat, a
pharmaceutically acceptable salt of omapatrilat, gemopatrilat, a pharmaceutically
acceptable salt of gemopatrilat, or an effective amount of the combination of a diuretic and
the vasopeptidase inhibitor omapatrilat, a pharmaceutically acceptable salt of omapatrilat,
gemopatrilat, or a pharmaceutically acceptable salt of gemopatrilat.
THE REFERENCES OF RECORD
As evidence of obviousness, the examiner relies upon the following references:
Robl 5,508,272 Apr. 16, 1996
Lis et al. (Lis) Vascular dementia, hypertension and the brain, “Neurological Research”,
Oct. 1997; 19:471-480
Wyss et al. (Wyss) Neurologic consequences of hypertension and antihypertensive drug
therapy, “Current Opinion in Nephrology and Hypertension, 1994; 3:228-235
THE REJECTION
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