Ex Parte Xu et al - Page 8




          Appeal No. 2003-1920                                                        
          Application No. 09/538,455                                                  


          We find that Upchurch also teaches that it is conventional to               
          employ a check valve with a disposable filter for regulating the            
          flow of a liquid in liquid chromatography.  See column 1, line 5            
          to column 2, line 30 and the abstract.  Thus, we concur with the            
          examiner that one of ordinary skill in the art would have been              
          led to place filters in the claimed locations, e.g., proximate a            
          sample point (between a sample point and a stream switching                 
          portion) and/or in a pressure regulation device (check valve) as            
          taught by Upchurch, with a reasonable expectation of successfully           
          reducing contaminants in a stream switching system used in liquid           
          chromatography, such as the one described in Higdon.  This is               
          especially true in this case since one of ordinary skill in the             
          art desiring to reduce the contaminant problem in a stream                  
          switching system as taught by Higdon would have readily observed            
          such problem in the claimed locations and would have placed                 
          therefore filters to prevent or minimize such problem.  See In re           
          Ludwig, 353 F.2d 241, 147 USPQ 420 (CCPA 1965).                             
                                     CONCLUSION                                       
               In summary:                                                            
          1) The examiner’s Section 102(e) rejection of claims 1 through 8,           
          20 through 24 and 26 through 30 is reversed;                                


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