Appeal No. 2003-1920 Application No. 09/538,455 We find that Upchurch also teaches that it is conventional to employ a check valve with a disposable filter for regulating the flow of a liquid in liquid chromatography. See column 1, line 5 to column 2, line 30 and the abstract. Thus, we concur with the examiner that one of ordinary skill in the art would have been led to place filters in the claimed locations, e.g., proximate a sample point (between a sample point and a stream switching portion) and/or in a pressure regulation device (check valve) as taught by Upchurch, with a reasonable expectation of successfully reducing contaminants in a stream switching system used in liquid chromatography, such as the one described in Higdon. This is especially true in this case since one of ordinary skill in the art desiring to reduce the contaminant problem in a stream switching system as taught by Higdon would have readily observed such problem in the claimed locations and would have placed therefore filters to prevent or minimize such problem. See In re Ludwig, 353 F.2d 241, 147 USPQ 420 (CCPA 1965). CONCLUSION In summary: 1) The examiner’s Section 102(e) rejection of claims 1 through 8, 20 through 24 and 26 through 30 is reversed; 8Page: Previous 1 2 3 4 5 6 7 8 9 10 NextLast modified: November 3, 2007