Interference 104,066
methods recited in the referenced claims encompass a method of diagnosis when said
claims describe introducing a wild-type p53 gene into a specific cancer cell. We point
out that the claims are directed to a method of introducing a wild-type p53 tumor
13. The method of claim 11 wherein the tumor cell is a breast tumor
cell.
14. The method of claim 11 wherein the tumor cell is a lung tumor cell.
15. The method of claim 11 wherein the tumor cell is a bladder tumor
cell.
16. The method of claim 11 wherein the tumor cell is a liver tumor cell
17. The method of claim 11 wherein the tumor cell is a leukemia cell.
18. The method of claim 11 wherein the tumor cell is an osteosarcoma
cell.
19. The method of claim 11 wherein the tumor cell is a prostate tumor
cell.
20. The method of claim 11 wherein the tumor cell is a stomach tumor
cell.
21. The method of claim 11 wherein the tumor cell is a brain tumor cell.
22. The method of claim 11 wherein the tumor cell is a mesenchyme
tumor cell.
Vogelstein’s claims 1 and 11 from which claims 12-22 depend read as follows:
1. A method of supplying wild-type p53 gene function to a cell which
has lost said gene function by virtue of a mutation in a p53 gene,
comprising:
introducing a wild-type p53 gene into a cell which has lost said
gene function such that said gene is expressed in the cell.
11. The method of claim 1 wherein the cell which has lost wild-type p53
gene function is a tumor cell.
14
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