Ex Parte HAYDEN et al - Page 1



                           The opinion in support of the decision being entered today was not written                   
                                   for publication and is not binding precedent of the Board.                           

                                                                                           Paper No. 45                 

                         UNITED STATES PATENT AND TRADEMARK OFFICE                                                      
                                                    __________                                                          

                              BEFORE THE BOARD OF PATENT APPEALS                                                        
                                             AND INTERFERENCES                                                          
                                                     __________                                                         
                                          Ex parte MICHAEL R. HAYDEN,                                                   
                                                   YUANHONG MA,                                                         
                                               SUZANNE LEWIS, and                                                       
                                                   GUOQUING LIU                                                         
                                                     __________                                                         
                                               Appeal No. 2003-1170                                                     
                                             Application No. 08/817,192                                                 
                                                     __________                                                         
                                              HEARD: January 6, 2004                                                    
                                                     __________                                                         
              Before WILLIAM F. SMITH, GRIMES, and GREEN,  Administrative Patent Judges.                                
              WILLIAM F. SMITH, Administrative Patent Judge.                                                            
                                               DECISION ON APPEAL                                                       
                     This is an appeal under 35 U.S.C. § 134 from the final rejection of claims 50                      
              through 57, all the claims pending in the application.  Claim 50 is representative of the                 
              subject matter on appeal and reads as follows:                                                            
                     50.  A method for preventing or delaying the onset of coronary artery disease in                   
              a human individual having lipoprotein lipase enzyme in which a serine residue is                          
              present at amino acid 291 in the enzyme, comprising administering to the individual a                     
              polynucleotide encoding a replacement lipoprotein lipase enzyme, said replacement                         
              lipoprotein lipase enzyme having an asparagine residue as amino acid 291 in the                           
              replacement enzyme, wherein the replacement lipoprotein lipase gene is expressed in                       
              the individual to produce a functional lipoprotein lipase enzyme.                                         
                     The references relied upon by the examiner are:                                                    





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