Appeal No. 2003-2017 Page 4
Application No. 09/802,116
The specification also discloses that “NHP oligonucleotides can be used
as hybridization probes for screening libraries, and assessing gene expression
patterns (particularly using a micro array or high-throughput ‘chip’ format).” Page
5. Such “[a]ddressable arrays comprising sequences first disclosed in SEQ ID
NOS:1-2 can be used to identify and characterize the temporal and tissue
specific expression of a gene.” Page 6.
Microarray-based analysis allows the discovery of broad patterns of
genetic activity, providing new understanding of gene functions and
generating novel and unexpected insight into transcriptional
processes and biological mechanisms. The use of addressable
arrays comprising sequences first disclosed in SEQ ID NOS:1-2
provides detailed information about transcriptional changes
involved in a specific pathway, potentially leading to the
identification of novel components or gene functions that manifest
themselves as novel phenotypes.
Pages 6-7. According to the specification, the claimed polynucleotides are also
useful in: “drug discovery” (page 7); “monitoring both drug action and toxicity”
(id.); and “identify[ing] mutations associated with a particular disease” (id.).
The specification discloses that the polypeptide encoded by the claimed
polynucleotides also has
a variety of uses. These uses include but are not limited to the
generation of antibodies, as reagents in diagnostic assays, the
identification of other cellular gene products related to the NHP,
[and] as reagents in assays for screening for compounds that can
be used as pharmaceutical reagents useful in the therapeutic
treatment of mental, biological, or medical disorders and disease.
Page 16. Finally, the specification discloses that antibodies that bind the
polypeptide encoded by the claimed polynucleotides are useful. They
can be used, for example, in the detection of NHP in a biological
sample and may, therefore, be utilized as part of a diagnostic or
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