Ex Parte Antheunisse et al - Page 6




          Appeal No. 2004-0290                                                        
          Application No. 09/742,692                                                  

          (page 12 of principal brief, second paragraph, emphasis added).             
          Appellants repeat in their reply brief the argument that “Beggs             
          does not appear to disclose the same antibody part, or other                
          stain-binding parts as those utilized in the present invention”             
          (page 2, second paragraph, emphasis added).  Manifestly, this               
          speculation on the part of appellants falls far short of                    
          establishing the requisite clear line of demarcation between                
          enzymes within the scope of claim 1 and those fairly disclosed by           
          Beggs.                                                                      
               As for appellants’ argument that Beggs does not suggest any            
          dependency or relationship between the pI value of the stain-               
          binding part of the enzyme and the pH of the wash solution, it is           
          not necessary for the reference to disclose such a property of              
          the enzyme that is inherently possessed.  Also, the question                
          arises, based on the close correspondence between appellants’ and           
          Beggs disclosure, how one of ordinary skill in the art would be             
          enabled to select enzymes having the claimed pI without resorting           
          to undue experimentation.  Totally lacking in appellants’                   
          principal and reply briefs is any argument that an actual                   
          specific enzyme, or class of enzymes, is not within the Beggs               
          disclosure.                                                                 



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