Ex Parte PLOUET et al - Page 8




                 Appeal No. 2004-0291                                                                                                              
                 Application No. 09/091,561                                                                                                        
                         Moreover, even if we assume for the sake of argument that the examiner had                                                
                 established a prima facie case of lack of enablement, we do not find the examiner has                                             
                 sufficiently addressed the Declaration argument and evidence made of record by                                                    
                 appellants in support of enablement which would appear to reasonably support                                                      
                 appellants position that the experimentation required to isolate the claimed antibodies                                           
                 was routine and used methodologies well known in the art.                                                                         
                         After evidence or arguments are submitted by the appellant in response to                                                 
                 rejection based on lack of enablement, patentability is determined on the totality of the                                         
                 record, by a preponderance of evidence with due consideration to persuasiveness of                                                
                 the argument.  On balance, we believe that the totality of the evidence presented by the                                          
                 examiner and appellant weighs in favor of finding the claimed invention is enabled by                                             
                 the present specification. The rejection of claims for lack of enablement is reversed.                                            


                                                               CONCLUSION                                                                          
                         The rejection of claims 25-30 and 32-35 under 35 U.S.C. 112, first paragraph for                                          
                 lack of enablement is reversed.                                                                                                   










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