Ex Parte Kovesdi et al - Page 22




                 Appeal No. 2004-1259                                                                                                             
                 Application No. 09/832,355                                                                                                       
                 therein.                                                                                                                         
                         Moreover, the examiner indicates in the rejection under 35 U.S.C.§ 102 that                                              
                 “Angiopoietin is known in the art to reduce [vessel] permeability”, meeting the limitations                                      
                 of claim 17.  Answer, page 13.   We do not find the examiner has established a prima                                             
                 facie case of lack of enablement supported by sufficient argument or evidence.  As we                                            
                 have found that the examiner has not established a prima facie case of lack of                                                   
                 enablement in the first instance, we do not reach appellants’ evidence in support of                                             
                 enablement.  The rejection of claim 17 for lack of enablement is reversed.                                                       


                         From the above, it would appear that the specification reasonably describes                                              
                 products having the claimed properties.   The rejection of claim 17 for lack of written                                          
                 description is reversed.                                                                                                         


                 35 U.S.C. §102(a)                                                                                                                
                         Claims 1-4, 9, 16-19, 32-34, 39-40 and 43-45 stand rejected under 35 U.S.C. §                                            
                 102(a), as anticipated by Davis.                                                                                                 
                         The examiner argues that (Answer, page 13):                                                                              
                         Davis [ ] disclose fusion proteins comprising the receptor binding domains                                               
                         of two ligands, which ligands may be the same or different, as well as                                                   
                         multimers thereof.  Preferred embodiments include Angiopoietin-1 and -2,                                                 
                         and EPH family ligands, see claims.  At page 9 a species comprising                                                      
                         VEGF and angiopoietin is specifically described, as is the definition that                                               
                         'receptor binding domain” is “the minimal portion of the ligand that is                                                  
                         necessary to bind it's receptor.”                                                                                        

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