Appeal No. 2004-1369 Page 2 Application No. 08/966,233 The references relied upon by the examiner are: Akhurst, et al. (Akhurst), “Transforming Growth Factor Betas in Mammalian Embryogenesis,” Progress in Growth Factor Research, Volume 2, pages 153- 168 (1990) Ernfors, et al. (Ernfors), “Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: Developmental and topographical expression in the brain,” Proceedings of the National Academy of Sciences, Volume 87, pages 5454-5458 (1990) Massague, “The Transforming Growth Factor-β Family,” Annual Review of Cell Biology, Volume 6, pages 597-641 (1990) Hoban, et al. (Hoban), “Activation of Second Messenger Pathways by GDF-1,” Society for Neuroscience Abstracts, Volume 19, page 653, Abst. No. 275.9, (1993) Ebendal, et al. (Ebendal ’95), “Glial Cell Line-Derived Neurotrophic Factor Stimulates Fiber Formation and Survival in Cultured Neurons From Peripheral Autonomic Ganglia,” Journal of Neuroscience Research, Volume 40, pages 276- 284 (1995) Krieglstein, et al. (Krieglstein), “Distinct Modulatory Actions of TGF-β and LIF on Neurotrophin-Mediated Survival of Developing Sensory Neurons,” Neurochemical Research, Volume 21, Number 7, pages 843-850 (1996) Bengtsson, et al. (Bengtsson), “Potentiating lnteractions Between Morphogenetic Protein and Neurotrophic Factors in Developing Neurons,” Journal of Neuroscience Research, Volume 53, pages 559-568 (1998) Ebendal, et al. (Ebendal ’98), “Bone Morphogenetic Proteins and Their Receptors: Potential Functions in the Brain,” Journal of Neuroscience Research, Volume 51, pages 139-146 (1998) Rankin, et al. (Rankin), “Regulation of left-right patterning in mice by growth/differentiation factor-1,” Nature Genetics, Volume 24, pages 262-265 (2000) GROUNDS OF REJECTION Claims 3, 11-15, 22 and 24-42 stand rejected under 35 U.S.C. § 101 as lacking utility and § 112, first paragraph, for lack of enablement based on the finding of lack of utility.Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 NextLast modified: November 3, 2007