Ex Parte Pickar - Page 5


             Appeal No. 2004-1478                                                               Page 5                
             Application No. 10/099,356                                                                               

                                                    Other Issues                                                      
                    During prosecution, Appellants submitted a copy of an International Search                        
             Report listing numerous references that were each individually deemed to render                          
             certain claims unpatentable.  To take just one example, the International Search Report                  
             lists PCT patent application WO 92/22457 (Morris) as an “X” category document; i.e., a                   
             document that renders the claims lacking in novelty or inventive step.                                   
                    Morris discloses treatment of osteoporosis by administration of estrogens in                      
             combination with ipriflavone.  See the abstract.  See also pages 5-6:  “The effect of the                
             combined administration of ipriflavone and estrogens were shown in a one year study                      
             carried out in corresponding groups of patients, in physiological menopause for 12-24                    
             months. . . .  Each group was treated according to a different therapeutic scheme: . . .                 
             group 4:  CE [conjugated estrogens] 0.15 mg/day + ipriflavone 600 mg/day.”  Morris                       
             discloses that “in the group of patients treated with Ip+CE 0.15 [i.e., ipriflavone plus 0.15            
             mg/day conjugated estrogens, see page 7] an effective control of the bone mass is                        
             attained after 6 months.”  Page 8.                                                                       
                    We are unable to discern any difference between the method defined by instant                     
             claim 12 and the method described by Morris in 1992, well before the filing date of the                  
             present application.  We have not reviewed any of the other references cited in the                      
             International Search Report but they may also be more applicable to the present claims                   
             than Plunkett.                                                                                           
                    Thus, it appears to us that the examiner has not applied the most relevant prior                  
             art.  We encourage the examiner, on return of this application, to review the prior art of               
             record.  If the examiner concludes that the record contains prior art that anticipates or                





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