Ex Parte Coleman et al - Page 3



             Appeal No. 2004-1934                                                               Page 3                
             Application No. 09/819,317                                                                               

             comprises linking agents.  The matrix is contacted with the laminate with the molecules                  
             being transferred from the matrix to the laminate.  The matrix is removed from the                       
             laminate and the laminate is shrunk so that the topographical surface area is greater                    
             than the projected surface area.                                                                         
                    There is no real dispute as to what the references teach.  Rather, the issue                      
             involved in this appeal is what conclusions should be reached on the basis of these                      
             facts.  The examiner has found without dispute from appellants that Halverson teaches                    
             a method of transferring molecules to a laminate.  The laminate described by Halverson                   
             is that required by claim 1 on appeal.  Furthermore, after the molecules are transferred                 
             to the laminate of Halverson, the laminate is shrunk in the manner required by claim 1                   
             on appeal.  See the fact-finding set forth on pages 4-5 of the Examiner’s Answer in                      
             regard to Halverson.                                                                                     
                    The examiner has identified, without dispute by appellants, that the difference                   
             between the method described in Halverson and that required by claim 1 on appeal is                      
             that Halverson does not explicitly teach that the molecules can be transferred to a                      
             laminate from a matrix.  The examiner relies upon Kreisher in this regard.                               
                    The examiner has found, again without dispute from appellants, that Kreisher                      
             describes electroblot transfer of molecules from a matrix to an immobilizing material.                   
             See the fact-finding set forth on pages 5-6 of the Examiner’s Answer.  On these facts,                   
             the examiner concludes:                                                                                  
                    It would have been prima facie obvious to one of ordinary skill in the art                        
                    at the time the invention was made to transfer the molecules onto the                             
                    laminates of Halverson using the electroblot method of Kreisher since                             
                    Halverson expressly states “‘Affix’ shall include any mode of attaching                           
                    reactants to a substrate.  Such modes shall include, without limitation,                          




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