Appeal No. 2004-1823 Page 5
Application No. 09/148,012
other lipoproteins via SR-BI to liver and steroidogenic tissues. Claim 1 was amended in
a paper received June 26, 2000, to read as follows:
A method for modifying steroid production in a mammal in need of treatment by
alteration of reproductive hormone levels comprising administering a compound altering
the transfer of cholesterol or cholesteryl ester from high density lipoprotein or other
lipoproteins [via] by specifically altering expression of or binding to cholesterol or
cholesteryl ester of SR-BI to [liver or] steroidogenic tissues producing reproductive
hormones.
Claim 1 was subsequently amended in a paper received January 5, 2001, to read
as follows:
A method for modifying steroid production in a mammal in need of treatment by
alteration of reproductive hormone levels comprising administering a compound directly
inhibiting SR-BI or a compound selectively increasing expression of SR-BI thereby
[compound] altering the transfer of cholesterol or cholesteryl ester from high density
lipoprotein or other lipoproteins by specifically altering expression of or binding to
cholesterol or cholesteryl ester of SR-BI to steroidogenic tissues producing reproductive
hormones.
Thereafter claim 1 was amended in a paper received July 17, 2001, to read as
follows:
A method for modifying steroid production in a mammal in need of treatment by
alteration of reproductive hormone levels comprising administering a compound directly
inhibiting SR-BI function or expression or a compound selectively increasing expression
of SR-BI thereby directly resulting in the selective alteration of cholesterol or cholesteryl
ester from high density lipoprotein or other lipoproteins by specifically altering
expression of or binding to cholesterol or cholesteryl ester of SR-BI to steroidogenic
tissues producing reproductive hormones, wherein the compound is selected from the
group consisting of SR-BI cDNA, SR-BI anti-sense nucleic acids,
SR-BI antibodies, and SR-BI receptor binding small molecules or proteins.
Up to this point in time, claim 1 was directed to methods for modifying steroid
production by administering compounds that affected SR-BI function. However, claim 1
was amended in a paper received February 21, 2002, to read as follows:
A method for altering fertility or treating a reproductive disorder in a mammal
comprising
Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 Next
Last modified: November 3, 2007