Ex Parte ANDERSEN et al - Page 4


                Appeal No.  2005-0908                                                  Page 4                  
                Application No.  09/261,329                                                                    

                Guidelines proffered by the United States Patent and Trademark Office                          
                (USPTO).  The court stated that:                                                               
                      The written description requirement can be met by “showing that an                       
                      invention is complete by disclosure of sufficiently detailed, relevant                   
                      identifying characteristics . . . i.e., complete or partial structure,                   
                      other physical and/or chemical properties, functional characteristics                    
                      when coupled with a known or disclosed correlation between                               
                      function and structure, or some combination of characteristics.                          
                Enzo Biochem, 296 F.3d at 1324, 63 USPQ2d at 1613 (citations omitted).                         
                      As an initial matter, we would like to address the construction of claim 204.            
                The claims recites “[a] modified cellulase, comprising a substitution of the amino             
                acid at position 119 with H in the amino acid of SEQ ID NO: 5, wherein each                    
                position is numbered according to the amino acid sequence of the cellulase of                  
                SEQ ID NO: 1 and the modified cellulase has endoglucanase activity.”  We                       
                construe the claim as requiring starting with a cellulase of SEQ ID NO: 5, in                  
                which the amino acid at position 119 has been replaced with H, but also                        
                encompassing other modifications to the sequence, wherein the modifications                    
                may be substitutions, insertions or deletions, with the proviso that the resulting             
                cellulose have endoglucanase activity.1                                                        
                      As to the merits of the rejection, Appellants argue that the specification               
                provides “a precise definition by structure of the genus of modified cellulases                
                sufficient to distinguish it from other modified cellulases” as well as “a description         












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