Ex Parte Mettrie et al - Page 6




               Appeal No. 2005-1655                                                                        Page 6                
               Application No. 09/852,624                                                                                        


               anionic surfactants with no further guidance provides evidence that selection of the appropriate                  
               surfactant was recognized as within the skill of the art.                                                         
                      Nor can we agree with Appellants that the surfactants of Lim would have been merely                        
               “obvious to try” in the composition of Tomura.  An invention is “obvious to try” where the prior                  
               art provides either no indication of which parameters would be critical or no direction as to                     
               which of many possible choices is likely to be successful.  Merck & Co. v. Biocraft Labs., Inc.,                  
               874 F.2d 804, 807, 10 USPQ2d 1843, 1845 (Fed. Cir.), cert. denied, 493 U.S. 975                                   
               (1989)(quoting In re O'Farrell, 853 F.2d 894, 903, 7 USPQ2d 1673, 1681 (Fed. Cir. 1988)).                         
               Here, the indication is that the selection of anionic surfactant is not particularly critical, it is the          
               alkali and polymer combination which is critical for stable solubilization of uric acid.  There is                
               no indication that anything more than routine experimentation is required to select the anionic                   
               surfactant that will be useful in the composition of Tomura.                                                      
                      Nor can we agree that the Examiner has failed to provide specific reasoning for                            
               combining the teachings of Lim with those of Tomura (Brief, p. 17).  Tomura directs one of                        
               ordinary skill in the art to select anionic surfactants for use in the hair dye composition discussed             
               therein and Lim provides evidence of what anionic surfactants were known in the art for use in                    
               hair dyes.  That one of ordinary skill in the art would have selected those typical anionic                       
               surfactants for their known properties flows from the disclosures in Tomura and Lim.                              
                      We conclude that Tomura’s suggestion that anionic surfactants can be appropriately                         
               added to the compositions of Tomura without any specific evidence that certain anionic                            







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