Ex Parte Huglin et al - Page 3



                Appeal No. 2004-1983                                                                  Page 3                                   
                Application No. 10/016,903                                                                                                     
                         for example, an emulsifier capable of providing a shearing force, such as a                                           
                         homomixer.                                                                                                            
                Page 2, line 54, to page 3, line 4 (emphasis added).                                                                           
                         Kakoki also expresses a preference for mixing methods that generate even                                              
                stronger shearing forces than a homomixer.  See page 4, lines 32-35  “[The                                                     
                composition] can be further improved when the mixture is treated in an emulsifier                                              
                capable of providing a stronger shearing force than a conventional homomixer.                                                  
                Examples of such emulsifiers are the Manthon Gaulin, the French press, the colloid mill,                                       
                the microfluidizer, and the sonication emulsifying machine.”  Consistent with these                                            
                preferences, in all of Kakoki’s working examples, emulsification is carried out using a                                        
                homomixer or stronger treatment.                                                                                               
                         In contrast, the instant specification discloses that                                                                 
                         Step (β) is carried out by adding the liquid obtained in step (α), the                                                
                         nanodispersion pre-phase, to the water phase of the cosmetic end                                                      
                         formulations.  The particular choice of components (a), (b) and (c) results                                           
                         directly in ultrafine, monodisperse nanodispersions.  In this case it is                                              
                         possible to forego homogenisation via nozzle, rotor-stator or ultrasound                                              
                         homogenisers, which is usually carried out to convert coarsely disperse or                                            
                         at least heterodisperse systems to fine monodisperse systems.  Step (β) is                                            
                         thus characterised by the absence of high shear or cavitation forces.                                                 
                Page 2, last paragraph (emphases added).  Consistent with this disclosure, all of the                                          
                working examples in the specification include a second mixing step (i.e., step (β) of the                                      
                claimed method) which is carried out “with stirring (e.g. using a magnetic agitator).”  See                                    
                pages 24-26.                                                                                                                   
                         On reconsideration of both the instant specification and the prior art, we think it is                                
                clear that the claimed method does not encompass a second step of mixing using a                                               
                homomixer, which was recognized in the art as subjecting compositions to a strong                                              
                shearing force.  See, e.g., Kakoki, page 3, lines 1-4.  We agree with Appellants that                                          




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