Appeal No. 2005-1422 Page 2
Application No. 09/997,522
b) a polypeptide comprising a naturally occurring amino acid
sequence, wherein the naturally occurring amino acid sequence
differs from the amino acid sequence of SEQ ID NO:2 by a
substitution of one amino acid residue and/or an insertion of 1-5
amino acid residues and/or a deletion of 1-5 amino acid residues,
c) a thrombin-binding fragment of a polypeptide, wherein the
polypeptide has the amino acid sequence of SEQ ID NO:2, and
d) an immunogenic fragment of a polypeptide having the amino acid
sequence of SEQ ID NO:2, wherein said fragment comprises at
least 13 contiguous amino acid residues of SEQ ID NO:2.
4. An isolated polynucleotide of claim 3 encoding a polypeptide comprising
the amino acid sequence of SEQ ID NO:2.
6. A recombinant polynucleotide comprising a promoter sequence operably
linked to a polynucleotide of claim 3.
9. A method of producing a polypeptide encoded by a polynucleotide of claim
3, the method comprising:
a) culturing a cell under conditions wherein the polypeptide is
expressed, and wherein said cell is transformed with a recombinant
polynucleotide, and said recombinant polynucleotide comprises a
promoter sequence operably linked to a polynucleotide of claim 3,
and
b) recovering the polypeptide so expressed.
12. An isolated polynucleotide selected from the group consisting of:
a) a polynucleotide comprising the polynucleotide sequence of SEQ
ID NO: 1,
b) a polynucleotide comprising a naturally occurring human variant of
the polynucleotide sequence of SEQ ID NO: 1,
c) a polynucleotide complementary to a polynucleotide of a),
d) a polynucleotide complementary to a polynucleotide of b), and
e) an RNA equivalent of a)-d).
The references relied upon by the examiner are:
Coleman el al. (‘597) 5,686,597 Nov. 11, 1997
Coleman et al. (‘633) 5,869,633 Feb. 9, 1999
Smith, et al. (Smith), “The challenges of genome sequence annotation or ‘The
devil is in the details,’” Nature Biotechnology, Vol. 15, pp. 1222-1223 (November
1997)
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