Appeal No. 2005-1422 Page 2 Application No. 09/997,522 b) a polypeptide comprising a naturally occurring amino acid sequence, wherein the naturally occurring amino acid sequence differs from the amino acid sequence of SEQ ID NO:2 by a substitution of one amino acid residue and/or an insertion of 1-5 amino acid residues and/or a deletion of 1-5 amino acid residues, c) a thrombin-binding fragment of a polypeptide, wherein the polypeptide has the amino acid sequence of SEQ ID NO:2, and d) an immunogenic fragment of a polypeptide having the amino acid sequence of SEQ ID NO:2, wherein said fragment comprises at least 13 contiguous amino acid residues of SEQ ID NO:2. 4. An isolated polynucleotide of claim 3 encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:2. 6. A recombinant polynucleotide comprising a promoter sequence operably linked to a polynucleotide of claim 3. 9. A method of producing a polypeptide encoded by a polynucleotide of claim 3, the method comprising: a) culturing a cell under conditions wherein the polypeptide is expressed, and wherein said cell is transformed with a recombinant polynucleotide, and said recombinant polynucleotide comprises a promoter sequence operably linked to a polynucleotide of claim 3, and b) recovering the polypeptide so expressed. 12. An isolated polynucleotide selected from the group consisting of: a) a polynucleotide comprising the polynucleotide sequence of SEQ ID NO: 1, b) a polynucleotide comprising a naturally occurring human variant of the polynucleotide sequence of SEQ ID NO: 1, c) a polynucleotide complementary to a polynucleotide of a), d) a polynucleotide complementary to a polynucleotide of b), and e) an RNA equivalent of a)-d). The references relied upon by the examiner are: Coleman el al. (‘597) 5,686,597 Nov. 11, 1997 Coleman et al. (‘633) 5,869,633 Feb. 9, 1999 Smith, et al. (Smith), “The challenges of genome sequence annotation or ‘The devil is in the details,’” Nature Biotechnology, Vol. 15, pp. 1222-1223 (November 1997)Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 NextLast modified: November 3, 2007