Ex Parte Ibrahim et al - Page 7




              Appeal No. 2005-1535                                                                                        
              Application No. 10/049,379                                                                                  
                     In view of the above, we agree with appellants that the examiner has failed to                       
              provide evidence to support a prima facie case of obviousness.  Nor does the examiner                       
              provide motivation for combination of the cited references.  The examiner has not                           
              indicated why one of ordinary skill in the art would have been motivated to incorporate                     
              glycerol into an oxaliplatinum composition.   In our view, while Schlipalius relates to an                  
              intravenous composition comprising glycerol, Schlipalius does not suggest that adding                       
              glycerol to oxaliplatinum would increase their concentration or solubility while                            
              maintaining shelf life.   While Schlipalius may have indicated to one of ordinary skill in                  
              the art that beta carotene could be delivered intravenously in glycerol, in view of the                     
              solubility spectrum of oxaliplatinum as set forth in the specification, we do not find                      
              Schilpalius provides motivation to deliver oxaliplatinum in glycerol or that one of ordinary                
              skill in the art would have been motivated to do so with an expectation of success.                         
                     In view of the above, the rejection of the claims for obviousness over Ibrahim in                    
              view of Schlipalius is reversed.                                                                            


                                                     CONCLUSION                                                           
                     The rejection of claims 1-11 and 15-17 for obviousness over Ibrahim and                              
              Schlipalius is reversed.                                                                                    






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