Ex Parte Khan et al - Page 6


              Appeal No. 2005-2446                                                                 Page 6                
              Application No. 09/951,099                                                                                 

                     According to Dawson, “suitable hydratable polysaccharides are the                                   
              galactomannan gums, glucomannan gums, guars, derived guars and cellulose                                   
              derivatives” (id., column 3, lines 21-24).  “Suitable enzyme breakers include, for                         
              example, the cellulases . . . [which] specific[ally] [ ] degrade the particular polymeric                  
              linkage found on the polysaccharide polymer backbone of the crosslinked gel, for                           
              instance, the 1,4 linkage between mannose in galactomannans” (id., column 4, lines                         
              11-21).  Finally, according to Dawson, “[a]ny conventional buffer can be used to adjust                    
              the pH, for instance aqueous potassium carbonate” (id., column 5, lines 1-2).                              
                     The examiner acknowledges that “Dawson differs from the claims in not disclosing                    
              the use of . . . ‘Tris’[ ] as the buffer in the [alkaline] pH adjustment step” (Examiner’s                 
              Answer, page 4), but relies on Segel’s list of “acids and bases that are useful in                         
              preparing buffers for enzyme assays” as evidence that “Tris is an extremely well known                     
              buffer, conventionally used in processes employing enzymes” (id.).  Moreover, the                          
              examiner notes that Tris “has an alkaline pKa of 8.1 and is therefore capable of providing                 
              buffering power in the alkaline range initially required in Dawson’s fracturing fluid” (id.).4             
              According to the examiner, “the artisan of ordinary skill clearly would have recognized                    
              Tris as being a conventional buffer suitable for processes employing enzymes, [thus,] the                  
              claimed substitution of Tris into Dawson’s process must be . . . considered obvious” (id.,                 
              pages 4 and 5).                                                                                            
                     Appellants argue that the examiner’s conclusion is unfounded because, among                         
              other things, “[t]he only specific reference to Tris buffer systems having a particular pH in              

                                                                                                                         
              4  We note that the pKa value provided here is for Tris at 25°.                                            





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