Appeal No. 2005-2671
Application No. 09/971,774
2. The method of claim 1 wherein, after closing said surgical opening, said taurolidine,
taurultam or mixture thereof is administered to said patient by installation or intravenous
infusion.
3. The method of claim 2 wherein, further including the step of additionally administering
taurolidine, taurultam or a mixture thereof to said patient prior to forming said surgical
opening in said patient's abdomen.
4. The method of claim 1, further including the step of additionally administering
taurolidine, taurultam or a mixture thereof to said patient prior to forming said surgical
opening in said patient's abdomen.
6. The method of claim 5 wherein during said surgery, said administering said
taurolidine, taurultam or mixture thereof to said patient’s abdomen is conducted by
passing a solution containing said taurolidine, taurultam or mixture thereof through said
trocar tube so as to contact internal tissue of the patient with said solution.
9. The method of claim 8 wherein said solution further contains heparin, a heparin
derivative or hyaluronic acid.
10. The method of claim 6 further comprising the step of additionally introducing said
solution into said patient prior to said laparoscopic tumor surgery and prior to
introducing said trocar tube into said patient.
26. The method of claim 1 further comprising administering to said patient 5-fluorouracil
(5-FU) at a dosage within the range of about 0.1-1000 mg.
The prior art references cited by the examiner are:
Allgood et al. (Allgood) 5,176,651 Jan. 5, 1993
Nicolson et al. (Nicolson) 5,262,403 Nov. 16, 1993
Monson WO 92/00743 Jan. 23, 1992
Jacobi, C. A., et al. (Jacobi) "Peritoneal instillation of taurolidine and heparin for the
prevention of intraperitoneal tumor growth and trocar metastases in laparoscopic
operations using rats as a model" Langenbecks Arch. Chir.,Vol. 382, Supp. 1, pp. 31-36
(1997). [English Translation]
Physicians' Desk Reference, Entry for 5-Fluorouracil, pp. 2034-5 (1995).
Grounds of Rejection
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