Appeal No. 2006-0565 Page 2
Application No. 10/033,777
1. A stabilized liquid preparation comprising:
a. a protease or its proenzyme, wherein the protease or its
proenzyme activates blood coagulation factor VII;
b. at least one compound selected from the group consisting of
ornithine, diaminopimelic acid, agmatine, creatine, guanidinoacetic
acid, acetylornithine, citrulline, arginosuccinic acid, tranexamic acid,
and ε-aminocaproic acid or their salts and derivatives; and
c. wherein said preparation has a pH from 2.0 to 8.0.
3. The stabilized liquid preparation of claim 1, which additionally
comprises at least one nonionic detergent.
Claims 1, 3 and 5-21 stand rejected under 35 U.S.C. § 103(a) as being
obvious over the combination of Roemisch JP2 or Römisch EP,3 Sato,4 and Roy5
or Kessler.6 After careful review of the record and consideration of the issues
before us, we reverse.
DISCUSSION
Claim 1, as examined, is drawn to a stabilized liquid composition
comprising a protease or its proenzyme, wherin the protease or its proenzyme
activates blood coagulation factor VII, and tranexamic acid, wherein the
preparation has a pH from 2.0 to 8.0. See Response Dated April 10, 2003, page
2 (electing the species of tranexamic acid).
2 Roemisch et al. (Roemisch JP), JP 2000-023696, published January 25, 2000.
3 Römisch et al. (Römisch EP), EP 0952215 A2, published October 27, 1999.
4 Sato et al. (Sato), US 4,465,662, issued August 14, 1984.
5 Roy et al. (Roy), US 5,589,363, issued December 31, 1996.
6 Kessler et al. (Kessler), US 5,604,202, issued February 18, 1997.
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