Appeal No. 2006-0624 Page 2
Application No. 10/096,127
10. A method of treating psoriasis in a patient, said method comprising
administering to said patient an effective amount of an antibody to gamma
interferon wherein said antibody is selected from the group consisting of a
polyclonal antibody, a monoclonal antibody, a humanized antibody, a synthetic
antibody, a human antibody, and a biologically active fragment of an antibody,
wherein said biologically active fragment is a Fab fragment or a F(ab')2 fragment,
and combinations thereof.
Claims 10 and 12 stand rejected under 35 U.S.C. § 103(a) as being
obvious over the combination of Queen,2 Ashkenazi I3 or Ashkenazi II,4
Levinson5 and Enssle,6 or as obvious over the combination of Ashkenazi I or
Ashkenazi II, Novick,7 Levinson and Enssle. In addition, claim 22 stand rejected
under 35 U.S.C. § 103(a) as being obvious over the previous two combinations
of references as further combined with Tomassi.8 After careful review of the
record and consideration of the issues before us, we affirm.
BACKGROUND
Autoimmune disease results when an individual’s immune
system attacks his own organs or tissues, producing a clinical
condition associated with the destruction of that organ or tissue, as
exemplified by diseases such as rheumatoid arthritis, insulin-
dependent diabetes mellitus, acquired immunodeficiency syndrome
(“AIDS”), hemolytic anemias, rheumatic fever, Crohn’s disease,
Gullain-Barré syndrome, psoriasis, thyroiditis, Graves’ disease,
myasthenia gravis, glomerulonephritis, autoimmune hepatitis,
multiple sclerosis, systemic lupus erythematosus, etc. Blocking,
neutralizing or inhibiting the immune response or removing its
cause in these cases is, therefore, desirable.
2 Queen et al. (Queen), U.S. Pat. No. 6,180,370, issued January 30, 2001.
3 Ashkenazi et al. (Ashkenazi I), U.S. Pat. No. 6,558,661 B1, issued May 6, 2003.
4 Ashkenazi et al. (Ashkenazi II), WO 94/14467, published July 7, 1994.
5 Levinson, U.S. Pat. No. 5,721,351, issued February 24, 1998.
6 Enssle et al. (Enssle), U.S. Pat. No. 6,210,661 B1, issued April 3, 2001.
7 Novick et al. (Novick), EP 0416652 A2, published March 13, 1991.
8 Tomassi et al., (Tomassi), WO 86/04145, published Juky 17, 1986.
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