Ex Parte Langston et al - Page 3



                Appeal No. 2006-0881                                                                                                          
                Application No. 09/928,139                                                                                                    

                Miller et al. (Miller ‘261)   4,254,261   Mar.   3, 1981                                                                      
                Zeitlin et al. (Zeitlin)    5,733,756   Mar. 31, 1998                                                                         
                Zavareh     6,121,453   Sep.  19, 2000                                                                                        
                Harris et al. (Harris)    US 6,242,464 B1   June   5, 1002                                                                    
                Miller et al. (Miller), “Racemization of 6-oxo-2-piperidine-carboxylic acid enantiomers,”                                     
                Chemical Abstracts 94 :47148 (1981)                                                                                           
                Armstrong et al. (Armstrong), “Separation of Drug Stereoisomers by the Formation of                                           
                ß-Cyclodextrin Inclusion Complexes,” Science, Vol. 232, pages 1132-1135 (1986)                                                
                Barry et al. (Barry), “Racemization of .alpha.-amino acid esters by aliphatic ketones in the                                  
                presence of carboxylic acids,” Chemical Abstracts 119:73084 (1993)                                                            
                         Claim 1 is rejected under 35 U.S.C.§ 112, first paragraph, “for lack of description and                              
                enablement” (answer, page 6).                                                                                                 
                         Claims 1-6 and 8 are rejected under 35 U.S.C. § 103 (a) as being unpatentable over                                   
                Zeitlin or Armstrong in view of the Miller Chemical Abstracts, the Barry Chemical Abstracts or                                
                Miller ‘261.                                                                                                                  
                         Claims 1-8 are rejected under 35 U.S.C. § 103(a) as being unpatentable over the prior art                            
                referred to immediately above and further in view of Harris.                                                                  
                         Finally, claims 1-8 are rejected under the judicially created doctrine of obviousness-type                           
                double patenting as being unpatentable over claim 1 of Zavareh ‘453 in view of the Miller                                     
                Chemical Abstracts, the Barry Chemical Abstracts, or Miller ‘261 and further in view of Harris.                               



                                                                                                                                             
                (Footnote, continued)                                                                                                         
                Under these circumstances, it is appropriate to grant the appellants’ request on page 6 of the reply brief that these         
                newly cited references not be considered by the Board.  It follows that we have not considered and will not further           
                comment upon these newly cited references in our resolution of the subject appeal.                                            

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