Appeal No. 2006-2194 Page 3
Application No. 09/866,925
stranded complex of the DNA and RNA forms such that the C1
sequence forms hydrogen bonds with the T1 sequence and the C2
sequence forms hydrogen bonds with the T2 sequence. Because
the C1 sequence is adjacent to the C2 sequence, the T1 sequence
is brought physically close to the T2 sequence. This produces a
loop of between 1kb and 150kb in the DNA. Histone proteins
reduce the length of the DNA by binding 200 bases. Histone/DNA
complexes form six-fold symmetry chromatin assemblies. The
diameter of the chromatin assemblies is approximately 30nm.
Id. at 6-7.
The specification states that an algorithm has been developed “to
determine the connectron structure of any genome,” id. at 2, and Figure 8
provides an overall view of the algorithm, see id. at 25. The “connectron
invention” “depends only on sequence equivalency.” Id. at 28. As can be seen
in Figure 8, the algorithm analyzes a genome for possible connectrons.
Moreover, according to the specification, the physical experimentation process of
proving the existence and lifetimes of connectrons “is logically quite separate
from the computational experimentation that have been conducted from June of
1999 to May of 2001,” id. at 28, which has demonstrated the existence of
connectrons in prokaryotes, plants, higher animals and humans using publicly
available genomes, see id. at 35, 37 and 38.
Claim 20, which is only one of the eight independent claims, is drawn to:
A computer mediated method of identifying DNA sequences that
control the expression of different collections of genes in a genome
comprising detecting, by computer, one or more pairs of first and
second non-adjacent DNA sequences which could bind to one RNA
molecule such that a first RNA sequence in that RNA molecule can
bind a first non-adjacent DNA sequence and a second RNA
sequence in that RNA molecule can bind to a second non-adjacent
sequence.
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