Ex Parte Berggren et al - Page 5

                   Appeal 2006-2238                                                                                               
                   Application 10/168,709                                                                                         

                   phrase was regarded as a claim limitation, it would not distinguish over any                                   
                   other particles since determination of flow rates as recited in the claims                                     
                   depends on many factors such as the packing density, type of polymer                                           
                   material, use of solvent, and swelling rate of the solvent (Answer 3).  In                                     
                   other words, based on the above-noted factors, especially the amount or                                        
                   density of the packing, any particles could be packed into a chromatographic                                   
                   bed to produce the claimed flow rates.4                                                                        
                          In view of our claim construction as discussed above, and in view of                                    
                   the uncontested findings of the Examiner that Park discloses the two claimed                                   
                   steps (a) and (b) of claim 1 on appeal (Br. 4-8), we determine that the                                        
                   Examiner has established a prima facie case of anticipation which has not                                      
                   been adequately rebutted by Appellants' arguments.  Therefore, we affirm                                       
                   the Examiner’s rejection of claim 1, and claims 2, 6, 7, 9, 10, 14, 15, and 17-                                
                   19, which stand or fall with claim 1, under § 102(b) over Park.                                                
                          B.  The Rejection under § 103(a) over Park                                                              
                          The Examiner applies Park as discussed above, further finding that                                      
                   Park does not expressly teach cross-linking with electron beam radiation at a                                  
                   dosage of 0.1 to 20 Mrad (Answer 5).  However, the Examiner finds that                                         
                   Appellants admit that it was well known in this art to use electron beam or                                    
                   gamma radiation in the preparation of sorbents for use as biocompatible                                        
                   materials (id., citing the Specification 2, ll. 15-31).  From these findings, the                              
                                                                                                                                 
                   4 We also note that independent claim 10 on appeal, directed to the matrix                                     
                   product produced by the same process steps as recited in claim 1 on appeal,                                    
                   does not recite any permissible flow rates when packed into a                                                  
                   chromatographic bed.  Accordingly, it appears that this flow rate language is                                  
                   not essential to particularly point out the invention defined by the claims.                                   
                   See In re Stencel, supra.                                                                                      
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