Appeal No. 93-3623 Page 12
Application 07/629,690
Winter
30. We note that Winter teaches the desirability of fluid-
tight joints (2:12-53) in an apparatus for the cyclical analysis
of peptides (1:11-70).
Admitted prior art
31. Applicant's admitted prior art, specifically D.H.
Hawke et al., "Microsequence Analysis of Peptides and Proteins",
147 Analytical Biochemistry 315, 329 (June 1985), "noting that
Teflon[ ] is 'self-sealing', report[s] lower background levels®
and increased yields deemed to be consequent from a better seal
achieved in the all Teflon[ ] design as compared to the seal®
observed with the Hewick glass cartridge." (Paper 1 at 2-3.)
32. We find that the admitted prior art would have provided
the motivation to use the all-PTFE constructions suggested in the
other references, and that a person having ordinary skill in the
art would have understood that such a construction would have
been "self-sealing", obviating the need for additional seals or
adhesives.
33. We find that Appellant's declaration regarding his
comparative data with Hawke and the "best prior art" (Decl. I at
¶¶ 9-11) unpersuasive. Appellant states that "the Teflon[ ]®
version of the Hood cartridge reactor [used in Hawke] was the
most advanced sequencer reactor extant [and] represents the best
prior art available at the time the invention of claims 1-12 was
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